Hydrochloric Acid → 2,3,3,3-Tetrafluoro-2-methoxypropanoic acid

HRID 1591020

반응식

HRID 1591020 반응식
[C:1]([C:5]([C:9]([O:11]C)=[O:10])([O:7][CH3:8])[F:6])([F:4])([F:3])[F:2].[OH-].[K+].Cl>O>[CH3:8][O:7][C:5]([F:6])([C:1]([F:2])([F:3])[F:4])[C:9]([OH:11])=[O:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2775434Methyl 2-methoxytetrafluoropropionate

생성물 1

HCID 111058852,3,3,3-Tetrafluoro-2-methoxypropanoic acid수율 80%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of methyl 2-methoxytetrafluoropropionate formed in Example 1 (41.9 g), water (500 ml) and potassium hydroxide (56 g) was refluxed for 3 hours. The reaction mixture was acidified with 100 ml of equal parts hydrochloric acid and water and extracted with three 200 ml portions of ether. The combined ether extracts were dried over sodium sulfate. After evaporation of the ether, fractional distillation gave 2-methoxytetrafluoropropionic acid (31.0 g. 80%), b.p. 67°-68° (12 mm Hg).

후처리

  1. temperaturewas refluxed for 3 hours
  2. extractionextracted with three 200 ml portions of ether
  3. dry with materialThe combined ether extracts were dried over sodium sulfate
  4. customAfter evaporation of the ether, fractional distillation

출처 및 근거

ORD 기록
ord-f764b3baaae641feacb45823580c77e4
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05205914

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