Sodium Acetate → N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide

HRID 1591285노트

반응식

HRID 1591285 반응식
[C:1]([O-])(=[O:3])[CH3:2].[Na+].CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O.[NH2:30][C:31]1[S:32][CH:33]=[C:34]([O:38][CH2:39][CH3:40])[C:35]=1[C:36]#[N:37]>O>[C:1]([NH:30][C:31]1[S:32][CH:33]=[C:34]([O:38][CH2:39][CH3:40])[C:35]=1[C:36]#[N:37])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 137423802-Amino-4-ethoxythiophene-3-carbonitrile

생성물 1

HCID 13742383N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

100 parts of anhydrous sodium acetate are introduced into 400 parts by volume of acetic anhydrice, 168 parts of 2-amino-3-cyano-4-ethoxythiophene are added and the mixture is refluxed for 4 hours. Thereafter, 800 parts of water are added dropwise to the hot mixture, the mixture is left to cool and the product is filtered off under suction, washed with water and dried to give 194 parts of 2-acetylamino-3-cyano-4-ethoxythiophene of melting point 242°-243° C. (from acetic acid).

후처리

  1. additionare added
  2. temperaturethe mixture is refluxed for 4 hours
  3. waitthe mixture is left
  4. temperatureto cool
  5. filtrationthe product is filtered off under suction
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-4896cfd6cedd464f922884e9b88f535a
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206375

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