Thiophenol → 2-Amino-3-cyano-5-formyl-4-phenylthiothiophene

HRID 1591298노트

반응식

HRID 1591298 반응식
[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5](Cl)[C:6]=1[C:7]#[N:8].[C:12]1([SH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C[O-].[Na+]>CO>[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5]([S:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]#[N:8]

참가 물질

5

반응물 3

HCID 7969ThiophenolHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 197667672-Amino-3-cyano-5-formyl-4-phenylthiothiophene수율 81%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

18.7 parts of 2-amino-4-chloro-3-cyano-5-formylthiophene are added to a solution of 11 parts of thiophenol, 5.4 parts of a 30% strength methanolic sodium methylate solution and 100 parts of methanol. The mixture is heated at the boil for 0.5 hour, after which it is allowed to cool and the precipitated product is filtered off under suction, washed with methanol, and then with water and dried. 21 parts (81% of theory) of 2-amino-3-cyano-5-formyl-4-phenylthiothiophene are obtained.

후처리

  1. temperatureThe mixture is heated at the boil for 0.5 hour
  2. temperatureto cool
  3. filtrationthe precipitated product is filtered off under suction
  4. washwashed with methanol
  5. dry with materialwith water and dried

출처 및 근거

ORD 기록
ord-70ddab2daf19419bbaa22ed55c413ed2
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206375

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