Benzenesulfinic acid, sodium salt → 2-Amino-3-cyano-5-formyl-4-phenylsulfonylthiophene

HRID 1591301노트

반응식

HRID 1591301 반응식
[C:1]1([S:7]([O-:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[NH2:11][C:12]1[S:13][C:14]([CH:20]=[O:21])=[C:15](Cl)[C:16]=1[C:17]#[N:18]>O>[NH2:11][C:12]1[S:13][C:14]([CH:20]=[O:21])=[C:15]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[C:16]=1[C:17]#[N:18]

참가 물질

4

반응물 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile

생성물 1

HCID 138792242-Amino-3-cyano-5-formyl-4-phenylsulfonylthiophene수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 82 parts of sodium phenylsulfinate in 500 parts of water is added to a mixture of 93.3 g of 2-amino-4-chloro-3-cyano-5-formylthiophene an 500 parts of methylglycol, and the reaction mixture is heated at the boil for 6 hours. Thereafter, the solution is filtered while hot and the filtrate is left to stand overnight. The precipitated product is then filtered off under suction, washed with water and dried. 121 parts (83% of theory) of 2-amino-3-cyano-5-formyl-4-phenylsulfonylthiophene are obtained.

후처리

  1. temperaturethe reaction mixture is heated at the boil for 6 hours
  2. filtrationThereafter, the solution is filtered while hot and the filtrate
  3. waitis left
  4. filtrationThe precipitated product is then filtered off under suction
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-c097305c49444c68816d24638c9acec1
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206375

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