1-((Tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid → 1-t-Butoxycarbonylamino-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-cyclohexanecarboxamide

HRID 1591434

반응식

HRID 1591434 반응식
[C:1]([O:5][C:6]([NH:8][C:9]1([C:15]([OH:17])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:18][CH:19]1[CH2:25][CH2:24][C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[NH:21][C:20]1=[O:30]>>[C:1]([O:5][C:6]([NH:8][C:9]1([C:15]([NH:18][CH:19]2[CH2:25][CH2:24][C:23]3[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=3[NH:21][C:20]2=[O:30])=[O:17])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

3

반응물 2

HCID 27947441-((Tert-butoxycarbonyl)amino)cyclohexanecarboxylic acidHCID 44344333-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one

생성물 1

HCID 190254701-t-Butoxycarbonylamino-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-cyclohexanecarboxamide

실험 절차

Prepared from 1-(t-butoxycarbonylamino)cyclohexanecarboxylic acid and 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step A) by the procedure described in Example 25, Step A. 1H NMR (200 MHz, CDCl3): 1.1-2.2 (m,19H), 2.00 (m,2H), 2.50 (m,2H), 4.55 (m,1H), 6.9-7.2 (m,4H). FAB-MS: calculated for C22H31N3O4 401; found 402 (M+H,40%).

출처 및 근거

ORD 기록
ord-fe53e65640ce4f9780c86459b9982f21
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05206235

연결된 노트

불러오는 중…