(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amine → 4-(5-Chloro-2-methyl-phenyl)-6-methoxy-[1,3,5]triazin-2-yl-amine

HRID 1591605

반응식

HRID 1591605 반응식
BrC1C=CC([NH:8][C:9]2[N:14]=[C:13](Cl)[N:12]=[C:11]([C:16]3[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=3[CH3:23])[N:10]=2)=CC=1.[CH3:24][O-:25].[Na+]>CO>[Cl:22][C:20]1[CH:19]=[CH:18][C:17]([CH3:23])=[C:16]([C:11]2[N:12]=[C:13]([O:25][CH3:24])[N:14]=[C:9]([NH2:8])[N:10]=2)[CH:21]=1

참가 물질

4

반응물 2

HCID 10179730(4-Bromo-phenyl)-[4-chloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazin-2-YL]-amineHCID 10942334Sodium Methoxide

생성물 1

HCID 1317266574-(5-Chloro-2-methyl-phenyl)-6-methoxy-[1,3,5]triazin-2-yl-amine수율 59%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of the title compound of Example 20 (100 mg, 0.25 mmol) in methanol (5 ml) was added a solution of sodium methoxide in methanol (25-30%, 0.5 ml). After stirring for 72 hours, the mixture was concentrated under reduced pressure. The residue was stirred with water (20 ml). The solid was collected by filtration, washed with hexane (5 ml), and dried under reduced pressure to provide the title compound (60 mg, 59% yield). 1H NMR (DMSO-d6) 10.40 (s, 1H), 7.90 (s, 1H), 7.75 (m, 2H), 7.48-7.55 (m, 3H), 7.38 (m, 1H), 3.98 (s, 3H), 2.54 (s, 3H).

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. stirringThe residue was stirred with water (20 ml)
  3. filtrationThe solid was collected by filtration
  4. washwashed with hexane (5 ml)
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-f7548e055b5847ea964530d212501469
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07291616B2

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