Water → HCID 21114633, 화합물
반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.C(N(CC)CC)C.[C:17]([NH2:20])#[C:18][CH3:19].O>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:20][CH2:17][C:18]#[CH:19])[C:5]([F:9])=[CH:4][N:3]=1참가 물질
6
실험 절차
11.1 g (66 mmol) of 2,4-dichloro-5-fluoropyrimidine is dissolved in 60 ml of acetonitrile, and 10.2 ml (73 mmol) of triethylamine and 6.0 ml (86 mmol) of propynylamine are added. The reaction mixture is stirred overnight at room temperature and then poured into water. The mixture is extracted by means of ethyl acetate, the combined organic phases are dried on MgSO2, and the solvent is evaporated by means of underpressure. After the remaining material is recrystallized with diisopropyl ether/hexane, the yield is 10.6 g (87% of theory) of the product.
후처리
- extractionThe mixture is extracted by means of ethyl acetate
- customthe combined organic phases are dried on MgSO2
- customthe solvent is evaporated by means of underpressure
- customAfter the remaining material is recrystallized with diisopropyl ether/hexane
출처 및 근거
- ORD 기록
- ord-650ca830d5bc446b91534912bd08a48c
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07291624B2
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