Triethylamine → 2,3-Dichloro-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzenesulphonamide

HRID 1591753노트

반응식

HRID 1591753 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH2:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][NH:18][C:17]1=[O:21].C(N(CC)CC)C>O1CCCC1>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([NH:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][NH:18][C:17]1=[O:21])(=[O:11])=[O:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 80480N-(2-Aminoethyl)ethyleneureaHCID 27342222,3-Dichlorobenzene-1-sulfonyl chloride

생성물 1

HCID 586387222,3-Dichloro-N-[2-(2-oxoimidazolidin-1-yl)ethyl]benzenesulphonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 0.5 g (2.04 mmol) of 2,3-dichlorobenzenesulphonyl chloride, 0.26 g (2.04 mmol) of 1-(2-aminoethyl)-2-imidazolidone and 1 ml (7.18 mmol) of triethylamine in 10 ml of tetrahydrofuran was stirred at room temperature overnight. The reaction mixture was then washed with 1 N HCl and saturated sodium bicarbonate solution, dried over sodium sulphate and concentrated. The product obtained in this manner was reacted further without additional purification.

후처리

  1. washThe reaction mixture was then washed with 1 N HCl and saturated sodium bicarbonate solution
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated
  4. customThe product obtained in this manner
  5. customwas reacted further without additional purification

출처 및 근거

ORD 기록
ord-18eb763fb5204c349306c5ee48c1e0dd
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07291642B2

반응 노트

불러오는 중…