Sodium Sulfite → 1,2-Benzisoxazole-3-methanesulfonate sodium

HRID 1591957노트

반응식

HRID 1591957 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[O:9][N:8]=[C:7]([CH2:10][S:11]([OH:14])(=[O:13])=N)[C:5]=2[CH:6]=1.BrCC1C2C=CC=CC=2[O:19]N=1.S([O-])([O-])=O.[Na+:30].[Na+]>>[Na+:30].[O:9]1[C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=2[C:7]([CH2:10][S:11]([O-:14])(=[O:19])=[O:13])=[N:8]1

참가 물질

4

반응물 3

HCID 24437Sodium SulfiteHCID 34991891,2-Benzisoxazole, 3-(bromomethyl)-HCID 119678001,2-Benzoxazol-3-ylmethanesulfonimidic acid

생성물 1

HCID 236749341,2-Benzisoxazole-3-methanesulfonate sodium

실험 절차

A process for the preparation of zonisamide, disclosed in U.S. Pat. No. 4,172,896, comprises the sulfonation of 3-bromomethyl-benzo[d]isoxazole (1) with sodium sulfite to obtain benzo[d]isoxazol-3-yl-methanesulfonic acid sodium salt (2) which is then transformed into the corresponding sulfonyl chloride (3) by treatment with phosphorous oxychloride. The reaction of the latter with gas ammonia yields zonisamide (4), as reported hereinbelow.

출처 및 근거

ORD 기록
ord-92c25a434cfe454498b138c684825bd0
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07291742B2

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