HCID 69414044, 화합물 → HCID 9978315, 화합물
반응식
C(OC([CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:18]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)=[N:19][N:20]([C:22]3[CH:23]=[CH:24][C:25]4[N:26]([CH:28]=[N:29][N:30]=4)[N:27]=3)[CH:21]=2)[CH:14]=[CH:13][N:12]=1)=O)(C)(C)C.C(OC(NC1C=C(C2C(C3C=CC(F)=CC=3)=NN(C3C=CC4N(C=NN=4)N=3)C=2)C=CN=1)=O)(C)(C)C>>[CH2:9]([NH:10][C:11]1[CH:16]=[C:15]([C:17]2[C:18]([C:31]3[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=3)=[N:19][N:20]([C:22]3[CH:23]=[CH:24][C:25]4[N:26]([CH:28]=[N:29][N:30]=4)[N:27]=3)[CH:21]=2)[CH:14]=[CH:13][N:12]=1)[CH3:8]참가 물질
3
실험 절차
The reaction was carried out in the same manner as in Example 8-2) except for using 659 mg (1.32 mmol) of 4-{2-[(t-butoxycarbonyl)ethylamino]pyridin-4-yl}-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained in Example 14-1) in place of 4-(2-t-butoxycarbonylaminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazole to obtain 413 mg of the title compound as a beige powder. (Yield: 78%)
출처 및 근거
- ORD 기록
- ord-76113f0bda794956a3dff681ecd03332
- 출처 데이터셋
- uspto-grants-2007_11