Potassium Carbonate → HCID 17864576, 화합물
반응식
[CH3:1][C:2]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)([CH3:5])[C:3]#[CH:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]#[N:21]>C(C(C)=O)C>[CH3:5][C:2]([N:6]1[CH2:7][CH2:8][N:9]([CH2:19][C:20]#[N:21])[CH2:10][CH2:11]1)([CH3:1])[C:3]#[CH:4]참가 물질
5
실험 절차
To a suspension (10 mL) of 1-(1,1-dimethyl-2-propynyl)piperazine (350 mg, 2.3 mmol) and potassium carbonate (480 mg, 3.45 mmol) in methyl ethyl ketone (MEK) was added bromoacetonitrile (0.176 mL, 2.53 mmol), and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with MEK and filtered. The filtrate was concentrated to give the title compound (0.439 g, quantitative) as a white solid.
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-15682edb23f54c938c3e2e618456592d
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07294629B2
반응 노트
불러오는 중…