Cyclopropylamine → 2-(4-Amino-phenyl)-6-cyclopropylamino-7-fluoro-2H-isoquinolin-1-one
반응식
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=3)[C:9]2=[O:12])=[CH:4][C:3]=1OS(C(F)(F)F)(=O)=O.[CH:30]1([NH2:33])[CH2:32][CH2:31]1>>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([N:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][C:2]([F:1])=[C:3]([NH:33][CH:30]4[CH2:32][CH2:31]4)[CH:4]=3)[C:9]2=[O:12])=[CH:14][CH:15]=1참가 물질
3
실험 절차
An analogous C—N coupling procedure to that described in Example 7 was performed on trifluoro-methanesulfonic acid 7-fluoro-2-(4-nitro-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl ester (Example 6) using cyclopropylamine as the nucleophile. Reduction of the nitro group was effected using the procedure outlined in Example 9. ES-MS (M+H)+=310.
출처 및 근거
- ORD 기록
- ord-3e223fbcb8e84e298cbbc30a1cf91ba4
- 출처 데이터셋
- uspto-grants-2007_11
- DOI