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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1593052생성일: 2026년 10월 26일

1-Sulfonylurea → N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamide

https://huagongshe.com/reaction/1593052

반응식

참여 물질

역할이름HCID투입량
반응물1-SulfonylureaHCID 11819083—
반응물5-Cyanothiophene-2-sulfonamideHCID 22019526—
반응물[2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl esterHCID 58998471—
생성물N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamideHCID 69145254—

반응 단계

An analogous sulfonylurea coupling and de-protection procedure to that described in Example 29 was performed on [2-(4-Amino-phenyl)-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl]-methyl-carbamic acid tert-butyl ester (Example 9) and 5-cyanothiophene-2-sulfonamide to give N-({[4-(6-amino-7-fluoro-1-oxoisoquinolin-2(1H)-yl)phenyl]amino}carbonyl)-5-cyanothiophene-2-sulfonamide. ES-MS (M+H)+=498.1.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07294635B2
출처 데이터셋uspto-grants-2007_11
ORD IDord-6fc69de384d84036a81458b101a1a187
출처 메모uspto-grants-2007_11