2-Isopropylaniline → 4-Iodo-2-(propan-2-yl)aniline
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10])([CH3:3])[CH3:2].C([O-])(=O)C.[Na+].[Cl-].[I-:17]>C(O)(=O)C.C(OCC)(=O)C>[I:17][C:8]1[CH:7]=[CH:6][C:5]([NH2:10])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:9]=1참가 물질
6
실험 절차
To a solution of 2-isopropyl-phenylamine (262 mg, 1.94 mmol) and sodium acetate (159 mg, 1.94 mmol) in 5 mL acetic acid, was added iodide monochloride (409 mg, 2.58 mmol) at room temperature. The mixture was stirred at room temperature for 20 minutes, then diluted with ethyl acetate and washed with saturated sodium bicarbonate. The organic layers were combined and concentrated in vacuo to give a crude residue, which was purified by column chromatography (silica 5-25% EtOAc/hexane) to give 4-iodo-2-isopropyl-phenylamine.
후처리
- washwashed with saturated sodium bicarbonate
- concentrationconcentrated in vacuo
- customto give a crude residue, which
- customwas purified by column chromatography (silica 5-25% EtOAc/hexane)
출처 및 근거
- ORD 기록
- ord-418f422171b7461eaa9adc007a0f8c4b
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07294635B2
반응 노트
불러오는 중…