2-Chlorobenzylamine → HCID 43445075, 화합물

HRID 1593131노트

반응식

HRID 1593131 반응식
[N:1](=[C:3]([C:9]([CH3:11])=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5])O.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16]>C(#N)C>[CH2:7]([O:6][C:4]([C:3]1[N:1]=[C:15]([C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[Cl:12])[NH:16][C:9]=1[CH3:11])=[O:5])[CH3:8]

참가 물질

4

반응물 2

HCID 666482-ChlorobenzylamineHCID 178472877HCID 178472877, 화합물

생성물 1

HCID 43445075HCID 43445075, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 8.5 g of ethyl 2-oximinoacetoacetate in acetonitrile (100 ml) was added 7.5 ml of 2-chlorobenzylamine. The reaction mixture was then refluxed for 4 hours under argon atmosphere. After such time the reaction mixture was then concentrated in vacuo and the residue was triturated with warm ethylacetate for 10 minutes. After allowing to cool down to room temperature the solid was filtered and dried in vacuo to yield 11.3 g of a white powder, MS (ISP) 265.1 (M+H)+.

후처리

  1. temperatureThe reaction mixture was then refluxed for 4 hours under argon atmosphere
  2. concentrationAfter such time the reaction mixture was then concentrated in vacuo
  3. customthe residue was triturated with warm ethylacetate for 10 minutes
  4. filtrationwas filtered
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-7460c7adaf9049078e767f6f702d0fa5
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294644B2

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