Potassium tert-butoxide → 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

반응식

[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15](F)[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1.C[C:20](C)([O-:22])C.[K+]>>[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15]([O:22][CH3:20])[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1

참가 물질

반응물 2

HCID 23665647Potassium tert-butoxide

HCID 686919624-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile

생성물 1

HCID 686911704-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

실험 절차

The compound was synthesized in the similar manner as in Reference Example 4-1 using 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile and 1 equivalent of potassium tert-butoxide.

출처 및 근거

ORD 기록: ord-a0991420e7ee4ae0929b78f8c594acce
출처 데이터셋: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07297698B2

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