HCID 178500928, 화합물 → Methyl 1,6-dihydro-4-hydroxy-6-oxo-1-phenyl-3-pyridazinecarboxylate

HRID 15935

반응식

HRID 15935 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4](=[N:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:5](=[O:11])[CH2:6][C:7](OC)=[O:8]>ClC1C=CC=CC=1Cl>[CH3:1][O:2][C:3]([C:4]1[C:5]([OH:11])=[CH:6][C:7](=[O:8])[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:12]=1)=[O:20]

참가 물질

3

반응물 1

HCID 178500928HCID 178500928, 화합물

생성물 1

HCID 54686161Methyl 1,6-dihydro-4-hydroxy-6-oxo-1-phenyl-3-pyridazinecarboxylate수율 99.1%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

A mixture of 3-oxo-2-(phenylhydrazono)-pentanedioic acid dimethyl ester (4.38 g, 15.7 mmol) in 1,2-dichlorobenzene (15 mL) was refluxed. After 20 hours, the reaction mixture was concentrated under reduced pressure to give 3.83 g (99%) of the desired product.

후처리

  1. temperaturewas refluxed
  2. concentrationthe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-cb3c94322e864a7cad80e9ddbd971998
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732616B2

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