Aluminium lithium hydride → 2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethanamine
반응식
O=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)[C:3]([NH2:5])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[NH2:5][CH2:3][CH2:2][C:6]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A solution of 2-oxo-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), heated at reflux temperature for 8 h, cooled to 0° C. and quenched by addition of Rochelle's salt solution. The reaction mixture is extracted with CH2Cl2; the combined extracts are dried over MgSO4 and concentrated in vacuo to afford the title 6-azatryptamine product, which is used directly in step 4, below.
후처리
- temperatureheated
- temperatureat reflux temperature for 8 h
- customquenched by addition of Rochelle's salt solution
- extractionThe reaction mixture is extracted with CH2Cl2
- dry with materialthe combined extracts are dried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-3774b16d7a2d4142a6e9a3018c8f0c09
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07297705B2
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