Isovaleryl chloride → N-(4-(5-Cyano-1-methyl-1H-pyrrol-2-yl)phenyl)-3-methylbutanamide

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:16][CH:17]([CH3:22])[CH2:18][C:19](Cl)=[O:20]>>[C:14]([C:11]1[N:12]([CH3:13])[C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:19](=[O:20])[CH2:18][CH:17]([CH3:22])[CH3:16])=[CH:3][CH:4]=2)=[CH:9][CH:10]=1)#[N:15]

참가 물질

반응물 2

HCID 66054Isovaleryl chloride

HCID 160504305-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile

생성물 1

HCID 16037460N-(4-(5-Cyano-1-methyl-1H-pyrrol-2-yl)phenyl)-3-methylbutanamide

실험 절차

The title compound was prepared according to the general procedure for acylation of 5-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carbonitrile using 3-methyl-butyryl chloride (67 μL, 0.55 mmol) to provide N-[4-(5-cyano-1-methyl-1H-pyrrol-2-yl)phenyl]-3-methyl butanamide (0.042 g).

후처리

customThe title compound was prepared

출처 및 근거

ORD 기록: ord-85b5854606e649e48862b133ed7e8a84
출처 데이터셋: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07297713B2

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