(1S,2R)-(+)-Norephedrine → 2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chloro-n-((2s, 1r)-2-hydroxy-1-methyl-2-phenyl-ethyl)-benzamide

참여 물질

역할	이름	HCID	투입량
반응물	(1S,2R)-(+)-Norephedrine	HCID 4786	—
반응물	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid	HCID 16090663	—
생성물	2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chloro-n-((2s, 1r)-2-hydroxy-1-methyl-2-phenyl-ethyl)-benzamide	HCID 11518998	—

반응 단계

2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4-chlorobenzoic acid was coupled with (1S,2R)-(+)-norephedrine as in EXAMPLE 1, Part C. HPLC: RT=10.13 min. MS (ESI−): mass calcd. for C22H19ClN4O4S2, 502.05; m/z found, 501 [M−H]−. 1H NMR (400 MHz, CDCl3): 11.69 (s, 1H), 8.37 (dd, J=7.0, 1.0, 1H), 8.22 (dd, J=8.8, 1.0, 1H), 7.73 (d, J=2.0, 1H), 7.72 (dd, J=8.8, 7.0, 1H), 7.41-7.29 (m, 5H), 7.24 (d, J=8.4, 1H), 6.93 (dd, J=8.4, 2.0, 1H), 6.28 (br d, J=8.3, 1H), 4.98 (d, J=3.0, 1H), 4.45 (ddq, J=8.3, 6.9, 3.0, 1H), 2.60 (br s, 1H), 1.05 (d, J=6.9, 3H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07297816B2
출처 데이터셋	uspto-grants-2007_11
ORD ID	ord-48e278b9d7f0404691ef94b37a191045
출처 메모	uspto-grants-2007_11