Sodium ethoxide → 2-Methoxycarbonyl-(1RS,4aRS,8aRS)-perhydoisoquinoline-1-carboxylic acid ethyl ester

HRID 1594

반응식

HRID 1594 반응식
[C:1]([O:5][C:6]([CH:8]1[CH:17]2[CH:12]([CH2:13][CH2:14][CH2:15][CH2:16]2)[CH2:11][CH2:10][N:9]1[C:18]([O:20][CH3:21])=[O:19])=[O:7])(C)(C)[CH3:2].[O-]CC.[Na+]>CCO>[CH2:1]([O:5][C:6]([CH:8]1[CH:17]2[CH:12]([CH2:13][CH2:14][CH2:15][CH2:16]2)[CH2:11][CH2:10][N:9]1[C:18]([O:20][CH3:21])=[O:19])=[O:7])[CH3:2]

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 702272422-methoxycarbonyl-(1RS,4aSR,8aSR)-perhydoisoquinoline-1-carboxylic acid t-butyl ester

생성물 1

HCID 702266492-Methoxycarbonyl-(1RS,4aRS,8aRS)-perhydoisoquinoline-1-carboxylic acid ethyl ester수율 95.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-methoxycarbonyl-(1RS,4aSR,8aSR)-perhydoisoquinoline-1-carboxylic acid t-butyl ester (81.2 g, 273 mmol) in EtOH (500 mL) was added sodium ethoxide (21% in ethanol) (88.4 mL, 273 mmol) and the reaction mixture was refluxed (24 h). The organic solvent was evaporated in vacuo, ethyl acetate (400 mL) and water (100 mL) was added to the residue. The organic layer was separated, washed twice with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to afford an oil of pure title compound (70 g,0.95%); FAB-MS 270 (MH+); TLC Rf (A) 0.61.

후처리

  1. temperaturethe reaction mixture was refluxed (24 h)
  2. customThe organic solvent was evaporated in vacuo, ethyl acetate (400 mL) and water (100 mL)
  3. additionwas added to the residue
  4. customThe organic layer was separated
  5. washwashed twice with water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-270d72865aa54cd2959c3b0657ef5d22
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726159

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