Piperazine → Ethyl 2-(piperazin-1-yl)-1,3-thiazole-5-carboxylate

HRID 1594003

반응식

HRID 1594003 반응식
Br[C:2]1[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C(O)C>[N:12]1([C:2]2[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 3614103Ethyl 2-bromothiazole-5-carboxylate

생성물 1

HCID 54595879Ethyl 2-(piperazin-1-yl)-1,3-thiazole-5-carboxylate수율 93%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.02 g (5.0 mmol) of ethyl 2-bromothiazole-5-carboxylate and 4.31 g (50 mmol) of piperazine were dissolved in ethanol (20 ml) and the mixture was heated under reflux over a period of 4 h. The solution was then concentrated in vacuo, taken up in EA and washed successively with water and a satd aq. NaCl solution. Following drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo there were obtained 1.12 g (4.6 mmol, 93%) of ethyl 2-piperazin-1-ylthiazole-5-carboxylate.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux over a period of 4 h
  3. concentrationThe solution was then concentrated in vacuo
  4. washwashed successively with water
  5. dry with materialFollowing drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo

출처 및 근거

ORD 기록
ord-6b095b5db6f74b3ab4a55b43fd34cf20
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07300939B2

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