Trifluoroacetic acid → HCID 86587611, 화합물

HRID 1594060노트

반응식

HRID 1594060 반응식
C(OC(=O)C[N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[N:14]=1)(C)(C)C.F[C:22](F)(F)[C:23]([OH:25])=[O:24]>ClCCl>[F:19][C:15]1([CH2:22][C:23]([OH:25])=[O:24])[CH:16]=[CH:17][CH:18]=[C:13]([C:9]2[NH:8][CH:12]=[CH:11][N:10]=2)[NH:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68495227[2-(6-Fluoropyridin-2-yl)-imidazol-1-yl]acetic acid tert-butyl ester

생성물 1

HCID 86587611HCID 86587611, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of [2-(6-fluoropyridin-2-yl)-imidazol-1-yl]acetic acid tert-butyl ester (630 mg; 2.27 mmol) and trifluoroacetic acid (4 mL) in dichloromethane (4 mL) is stirred at room temperature for 5 hr. The reaction mixture is concentrated. The residue is treated with 3M HCl in ethyl acetate (10 mL) and the suspension stirred at room temperature for 1 hr. The precipitate is collected, washed with ethyl acetate, and dried to give 2-Fluoro-6-(1H-imidazol-2-yl)-pyridine acetic acid as a tan solid (581 mg), 1H NMR (d6DMSO) δ 8.35-8.26 (m, 2H), 7.83 (s, 1H), 7.76 (s, 1H), 7.44-7.41(m. 1H), 5.40 (s, 2H). LCMS: 222.1 (MH+).

후처리

  1. concentrationThe reaction mixture is concentrated
  2. additionThe residue is treated with 3M HCl in ethyl acetate (10 mL)
  3. customThe precipitate is collected
  4. washwashed with ethyl acetate
  5. customdried

출처 및 근거

ORD 기록
ord-ea9b04f08fb64bd2a8a52988974c3429
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07300945B2

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