Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 1594151

반응식

HRID 1594151 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

참가 물질

5

반응물 2

HCID 69888DiphenylsilaneHCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

생성물 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

시약·촉매·용매 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride촉매HCID 8028Tetrahydrofuran용매

실험 절차

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

출처 및 근거

ORD 기록
ord-eb186b723c8740239c979d6b6e8e25b5
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07300931B2

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