Triethylamine → 919482-29-4
반응식
[CH3:1][C:2]1([CH3:8])[O:6][CH2:5][CH:4]([OH:7])[O:3]1.[CH2:9](N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18].[Cl-].[NH4+]>O1CCCC1>[CH3:16][S:17]([O:7][CH:4]1[CH2:5][O:6][C:2]([CH3:8])([CH3:1])[O:3][CH2:9]1)(=[O:19])=[O:18]참가 물질
6
실험 절차
A 2,2-dimethyl-1,3-dioxolan-5-ol (743 mg) solution in tetrahydrofuran (10 mL) was cooled to 0° C. in nitrogen atmosphere. To the reaction mixture, triethylamine (1.87 mL) and methanesulfonyl chloride (520 μL) were successively added at 0° C., followed by 30 minutes' stirring. After addition of saturated aqueous ammonium chloride solution, the reaction mixture was extracted with ethyl acetate. The extract washed with saturated brine, dried over anhydrous magnesium sulfate and the solvent was removed by distillation to provide 837 mg of crude title compound as a colorless solid.
후처리
- extractionthe reaction mixture was extracted with ethyl acetate
- washThe extract washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was removed by distillation
출처 및 근거
- ORD 기록
- ord-5994f08bc24b4279a61f0e779823fb82
- 출처 데이터셋
- uspto-grants-2007_11
- 특허 번호
- US07300947B2
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