Hydrazine → [2,4'-Bipyridin]-5-amine

HRID 1594386노트

반응식

HRID 1594386 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1)([O-])=O.NN>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 111832665-nitro-2,4'-bipyridine

생성물 1

HCID 45788763[2,4'-Bipyridin]-5-amine수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

5-Nitro-2,4′-bipyridine (10 g) obtained in Example 1 was added to ethanol (400 ml). 10% Pd—C (50% wet with water) (0.14 g) was added, and then, hydrazine.monohydrate (10 g) was dropwise added, for reflux under heating for 3 hours. The reaction solution was filtered and concentrated. The resulting crystal was recrystallized in ethyl acetate, to obtain the object substance (8.13 g; yield of 95%).

후처리

  1. temperaturefor reflux
  2. temperatureunder heating for 3 hours
  3. filtrationThe reaction solution was filtered
  4. concentrationconcentrated
  5. customThe resulting crystal was recrystallized in ethyl acetate
  6. customto obtain the object substance (8.13 g; yield of 95%)

출처 및 근거

ORD 기록
ord-61da0351d59f4790a6623ea520f41c84
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07301029B2

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