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3-(Trifluoromethyl)cyclohexanone → (1RS,2RS,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

HRID 1594528
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반응식

HRID 1594528 반응식
[CH3:1][N:2]([CH2:4][CH:5]1[CH2:10][CH2:9][CH:8]([C:11]([F:14])([F:13])[F:12])[CH2:7][C:6]1=[O:15])[CH3:3].FC(F)(F)[CH:18]1[CH2:23][CH2:22][CH2:21][C:20](=[O:24])[CH2:19]1.CN(C(Cl)[Cl:31])C>C(#N)C>[ClH:31].[CH3:3][N:2]([CH2:4][CH:5]1[CH2:10][CH2:9][CH:8]([C:11]([F:14])([F:12])[F:13])[CH2:7][C:6]1([C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)[OH:15])[CH3:1]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 27793553-(Trifluoromethyl)cyclohexanoneHCID 10290805Dimethylaminomethylene chlorideHCID 21705850(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone

생성물 1

HCID 21705866(1RS,2RS,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The 5-epimer (27) of compound (25) was prepared, under the conditions given in Example 27, from (2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone, prepared from 3-trifluoromethyl-cyclohexanone and dimethylaminomethylene chloride in acetonitrile. (27) was obtained in a yield of 27% theoretical and had a melting point of 221°-223° C.

후처리

  1. customThe 5-epimer (27) of compound (25) was prepared, under the conditions

출처 및 근거

ORD 기록
ord-e2edfb3bf34348ae91b0ec94c5686ac9
출처 데이터셋
uspto-grants-2001_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
USRE037355E1

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