Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Bromomethyl)benzenesulfonyl chloride → (RS)-2-(4-Fluoro-phenyl)-1-(4-methoxymethyl-benzenesulfonyl)-pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Bromomethyl)benzenesulfonyl chloride | HCID 2734409 | — |
| 반응물 | 2-(4-Fluorophenyl)pyrrolidine | HCID 3865560 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | (RS)-2-(4-fluoro-phenyl)-1-(4-chloromethyl-benzenesulfonyl)-pyrrolidine | HCID 21706775 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (RS)-2-(4-Fluoro-phenyl)-1-(4-methoxymethyl-benzenesulfonyl)-pyrrolidine | HCID 21706731 | — |
반응 단계
Reaction of (RS)-2-(4-fluoro-phenyl)-1-(4-chloromethyl-benzenesulfonyl)-pyrrolidine (0.50 g, 1.41 mmol), which was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-bromomethyl-benzenesulfonyl chloride, with sodium methanolate in MeOH for 80 h at 50° C. yielded after crystallization from EE/hexane 0.28 g (52%) of the title compound as a white solid, m.p. 115° C., and MS: m/e=349 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06284785B1 |
| 출처 데이터셋 | uspto-grants-2001_09 |
| ORD ID | ord-ba6233d6c9034b0db398517187b81c97 |
| 출처 메모 | uspto-grants-2001_09 |