Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → (RS)-4-{4-[2-(4-Fluoro-phenyl)-pyrrolidine-1-sulfonyl]-benzyl}-morpholine fumarate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-(Bromomethyl)benzenesulfonyl chloride | HCID 2734409 | — |
| 반응물 | 2-(4-Fluorophenyl)pyrrolidine | HCID 3865560 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | (RS)-2-(4-fluoro-phenyl)-1-(4-chloromethyl-benzenesulfonyl)-pyrrolidine | HCID 21706775 | — |
| 생성물 | (RS)-4-{4-[2-(4-Fluoro-phenyl)-pyrrolidine-1-sulfonyl]-benzyl}-morpholine fumarate | HCID 69693329 | — |
반응 단계
Reaction of (RS)-2-(4-fluoro-phenyl)-1-(4-chloromethyl-benzenesulfonyl)-pyrrolidine (0.50 g, 1.41 mmol), which was prepared in accordance with the general method of example 1e from (RS)-2-(4-fluoro-phenyl)-pyrrolidine and 4-bromomethyl-benzenesulfonyl chloride, with morpholine (K2CO3, DMF, 80° C., 17 h) and subsequent formation of the fumarate (MeOH, diethyl ether) yielded the title compound as an off-white solid, m.p. 136° C., and MS: m/e=405.4 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06284785B1 |
| 출처 데이터셋 | uspto-grants-2001_09 |
| ORD ID | ord-3cfff8c53bbb4df2b0a992a18537a59c |
| 출처 메모 | uspto-grants-2001_09 |