홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Iodide → 3-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-5-methyl-thiazolidin-4-one

HRID 1594800
노트
인쇄 미리보기

반응식

HRID 1594800 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10](=[O:11])[CH:9]([CH3:12])[S:8][CH2:7]1.Cl.[S:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:16]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:15]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>C(#N)C>[S:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:16]([N:23]2[CH2:24][CH2:25][N:26]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:10](=[O:11])[CH:9]([CH3:12])[S:8][CH2:7]3)[CH2:27][CH2:28]2)=[N:15]1
참가 물질반응 조건실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 106822173-(4-Bromobutyl)-5-methyl-4-thiazolidinoneHCID 115217113-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride

생성물 1

HCID 107391723-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-5-methyl-thiazolidin-4-one수율 58.8%

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

반응 조건

온도
42.5 °C

실험 절차

A mixture of 3-(4-bromobutyl)-5-methyl-4-thiazolidinone (4.00 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (4.46 g), K2CO3 (8.00 g) and NaI (300 mg) in acetonitrile (210 ml) was heated at 40-45° C. for 64 hours and the product was processed in substantially the same manner as in Example 10 to afford 3.64 g of crystals, m.p. 113-115° C.

출처 및 근거

ORD 기록
ord-3dd988f34b8342ea95912430fa53faf3
출처 데이터셋
uspto-grants-2001_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06284775B1

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차출처 및 근거반응 노트