Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 4-oxo-3,4-dihydro-2H-pyran-2-carboxylate → Ethyl tetrahydro-4-oxo-2H-pyran-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 4-oxo-3,4-dihydro-2H-pyran-2-carboxylate | HCID 22495097 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl tetrahydro-4-oxo-2H-pyran-2-carboxylate | HCID 54067561 | 33.1% |
반응 단계
A mixture of 4-oxo-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester (8.0 g, 46.0 mmol) and Pd/C (10%, 0.20 g) in EtOAc (70 mL) was shaken in a Parr bottle with hydrogen at 50 psi overnight and filtered through a pad of Celite. The filtrate was concentrated and the residue was distilled to give 2.62 g (33%) of yellowish oil: 1H NMR (CDCl3) δ 1.29 (t, 3H), 2.40 (d, 1H), 2.58-2.75 (m 3H), 3.79 (tt, 1H), 4.23 (q, 2H), 4.28 (m 1H), 4.40 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06284764B1 |
| 출처 데이터셋 | uspto-grants-2001_09 |
| ORD ID | ord-98730daf56ff4475a1c7d90c76137141 |
| 출처 메모 | uspto-grants-2001_09 |