6-Methoxy-2-naphthaldehyde → HCID 178440904, 화합물

HRID 1594945

반응식

HRID 1594945 반응식
[Mg:1].C(C1C=C([Br:12])C=CC=1)=C(C)C.CO[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=C[CH:19]=[C:20]([CH:25]=O)[CH:21]=2)[CH:16]=1>C1COCC1>[CH:21]([C:22]1[CH:17]=[C:16]([Mg:1][Br:12])[CH:15]=[CH:24][CH:23]=1)=[C:20]([CH3:25])[CH3:19]

참가 물질

5

반응물 3

HCID 769916-Methoxy-2-naphthaldehydeHCID 5462224MagnesiumHCID 217068361-Bromo-3-(2-methyl-1-propenyl)benzene

생성물 1

HCID 178440904HCID 178440904, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of Rieke magnesium (0.12 g, 4.74 mmol; commercially available suspension) in dry THF (4.61 mL) was added neat 3-(iso-buten-1-yl)-phenylbromide (1.0 g, 4.74 mmol) at such a rate as to maintain a steady reflux. After the arylbromide was completely added, the reaction was refluxed under nitrogen for 0.5 hours. The solution was allowed to settle for 18 hours and the supernatant was determined to have a 0.56 m titer for active grignard by tritrating a known quantity of 2-methoxynaphthalene-6-carboxaldehyde.

후처리

  1. temperatureto maintain a steady reflux
  2. temperaturethe reaction was refluxed under nitrogen for 0.5 hours

출처 및 근거

ORD 기록
ord-465df1866a874a6884707d2ab3413212
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06284796B1

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