Bromine → 2-Bromobenzocycloheptan-1-one

HRID 1595130

반응식

HRID 1595130 반응식
[C:1]1(=[O:12])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:5]=2[CH:4]=[CH:3][CH2:2]1.[Br:13]Br>C(O)(=O)C>[Br:13][CH:2]1[C:1](=[O:12])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:5]=2[CH:4]=[CH:3]1

참가 물질

4

반응물 2

HCID 24408Bromine2회HCID 21703317Benzocycloheptan-1-one

생성물 1

HCID 217033152-Bromobenzocycloheptan-1-one

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

2-bromobenzocycloheptan-1-one was prepared by dissolving benzocycloheptan-1-one (25.15 g, 0.157 mol) in acetic acid (200 mL, 99.8%) in a 500 mL three neck flask. Bromine (25.15 g, 0.157 mol) and acetic acid (10 mL) were placed in a dropping funnel. The bromine was slowly added dropwise to the flask over 4 hours at room temperature. The reactor was kept under a static blanket of nitrogen throughout. Then the reaction was held at room temperature for an additional four hours. The reaction mixture was washed with water (200 mL×2) and dried over sodium sulfate. A brown colored liquid (30.2 g) as a crude product was obtained after filtration from the sodium sulfate. The purity of the product was 96.4% by GC (area %).

후처리

  1. washThe reaction mixture was washed with water (200 mL×2)
  2. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-d75ef2c8476e419db020bc95b77534f8
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06287749B1

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