[C:1](=[O:4])([O-])[O-].[K+].[K+].[OH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[CH:18]=[C:17]4[CH:23]=[CH:24][CH:25]=[CH:26][C:16]4=[CH:15][C:14]=3[NH:13][C:12]=2[CH:11]=[C:10](O)[CH:9]=1.[I-].[K+]>CN(C)C=O>[OH:7][C:8]1[CH:9]=[C:1]2[O:4][C:16]([CH3:26])([CH3:17])[CH:15]=[CH:10][C:11]2=[C:12]2[C:21]=1[C:20](=[O:22])[C:19]1[CH:18]=[C:17]3[CH:23]=[CH:24][CH:25]=[CH:26][C:16]3=[CH:15][C:14]=1[NH:13]22 g of anhydrous potassium carbonate are added to a solution of 2 g of the product of Step A in 50 ml of anhydrous dimethylformamide, under an inert atmosphere. After stirring for 15 minutes at 65° C., 2.4 g of anhydrous potassium iodide and 4.4 g of 3-chloro-3-nmethyl-1-butyne are added and the reaction mixture is maintained at 65° C. for 24 hours and then at 130° C. for 1 hour 30 minutes. After cooling, the solution is hydrolysed and then extracted with dichloromethane. The combined organic phases are washed with water and then with a 1M solution of potassium hydroxide, dried over sodium sulphate and then evaporated. After chromatography on silica gel (cyclohexane/acetone: 90/10), 1.10 g of the expected product are isolated.
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