4-Nitrobenzylamine → HCID 178470203, 화합물

참여 물질

반응 단계

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (50.0 g) and 4-nitrobenzylamine (50.0 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (58.0 g), which was dissolved in ethyl alcohol (1200 ml). Thereto was added 1 M sodium hydroxide solution (300 ml) and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(4-nitrophenyl)imidazole-4-carboxyic acid (37.6 g), melting point 212° C. (decomposition).

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