Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
[4-(Morpholin-4-ylmethyl)phenyl]methanamine → Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | [4-(Morpholin-4-ylmethyl)phenyl]methanamine | HCID 2795501 | — |
| 반응물 | HCID 178472894 | HCID 178472894 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate | HCID 178470186 | 61.5% |
반응 단계
4-(Morpholinomethyl)phenylmethylamine (8 g) and ethyl 3-(4-chlorophenyl) -2-hydroxyimino-3-oxopropionate (8.26 g) were dissolved in pyridine (120 ml) and the mixture was refluxed under heating for 12 hr. The solvent was evaporated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate (8.46 g), melting point 183-185° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06288061B1 |
| 출처 데이터셋 | uspto-grants-2001_09 |
| ORD ID | ord-d44807d35368431c8724c55ddde81c27 |
| 출처 메모 | uspto-grants-2001_09 |