4-Dimethylaminomethylbenzylamine → HCID 178470187, 화합물

HRID 1595379

반응식

HRID 1595379 반응식
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1)[CH3:3].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=O)[C:21](=[N:27]O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1>N1C=CC=CC=1>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[NH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([CH2:4][N:2]([CH3:3])[CH3:1])=[CH:6][CH:7]=3)=[N:27][C:21]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 1937144-DimethylaminomethylbenzylamineHCID 178472894HCID 178472894, 화합물

생성물 1

HCID 178470187HCID 178470187, 화합물수율 39.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-(Dimethylaminomethyl)phenylmethylamine (11.7 g) and ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate (15.1 g) were dissolved in pyridine (220 ml) and the solution was refluxed under heating for 12 hr. The solvent was concentrated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(dimethylaminomethyl)phenyl]imidazole-4-carboxylate (9.0 g), melting point 175-176° C.

후처리

  1. temperaturethe solution was refluxed
  2. temperatureunder heating for 12 hr
  3. concentrationThe solvent was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8990023815794cd68951d6363c30363a
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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