Water → HCID 178522576, 화합물

HRID 1595424노트

반응식

HRID 1595424 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1.B(Br)(Br)Br.O>ClCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 178489042HCID 178489042, 화합물

생성물 1

HCID 178522576HCID 178522576, 화합물수율 83.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-(4-Methoxyphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (2.1 g) obtained in Example 47 was dissolved in dichloromethane (210 ml) and boron tribromide (3 ml) was added. The mixture was stirred for one day. The reaction mixture was poured into cold water and the precipitated crystals were collected by filtration to give 5-(4-hydroxyphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (1.7 g).

후처리

  1. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-0f12a75a545649d1a5f3840447b7cf03
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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