Hantzsch ester → 5-([4-[2-(4-Cyanophenyl)ethoxy]phenyl]methyl)thiazolidine-2,4-dione

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반응 단계

3.9 g (11 mmole) 5-(4-[2-(4-cyanophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione and 3.88 g (15 mmole) diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate were mixed and heated to 210° C. under vacuum for 1 hour. The solid material was dissolved in ethyl acetate, evaporated in vacuo, purified by chromatography on silica gel with first dichloromethane, then dichloromethane:diethyl ether (95:5) and finally dichloromethane:methanol (95:5) as eluents. Crystallization in acetone/water gave 0.65 g (yield 17%) of the desired product.

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