Trifluoroacetic acid → 5-([4-[2-(4-Methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione

HRID 1595482노트

반응식

HRID 1595482 반응식
FC(F)(F)C(O)=O.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:15]2[C:19](=[O:20])[CH:18]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([O:37][S:38]([CH3:41])(=[O:40])=[O:39])=[CH:33][CH:32]=4)=[CH:24][CH:23]=3)[O:17][C:16]2=[O:42])C=CC=CC=1>ClCCl>[CH3:41][S:38]([O:37][C:34]1[CH:33]=[CH:32][C:31]([CH2:30][CH2:29][O:28][C:25]2[CH:26]=[CH:27][C:22]([CH2:21][CH:18]3[O:17][C:16](=[O:42])[NH:15][C:19]3=[O:20])=[CH:23][CH:24]=2)=[CH:36][CH:35]=1)(=[O:39])=[O:40]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 217049903-Triphenylmethyl-5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione

생성물 1

HCID 217050105-([4-[2-(4-Methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione수율 88.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

1 ml trifluoroacetic acid was added to a solution of 0.214 g (0.33 mmole) 3-triphenylmethyl-5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione in 10 ml dichloromethane. After stirring for 45 minutes at room temperature 20 ml more of dichloromethane was added, the reaction mixure was washed twice with water, dried (sodium sulfate) and the solvent was evaporated in vacuo. The crude product was purified by chromatography on silica gel using heptane:ethyl acetate:acetic acid (10:10:1) as eluent to give 0.118 g (yield 88%) of 5-([4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]methyl)oxazolidine-2,4-dione.

후처리

  1. additionwas added
  2. washthe reaction mixure was washed twice with water
  3. dry with materialdried (sodium sulfate)
  4. customthe solvent was evaporated in vacuo
  5. customThe crude product was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-293df3e401174385b38b570f7984d74c
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288096B1

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