Methanol → 2-(4-Methylsulfanylphenyl)ethanol

HRID 1595532노트

반응식

HRID 1595532 반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](O)=[O:11])=[CH:5][CH:4]=1.CO>O1CCCC1>[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][OH:11])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 49839124-(Methylthio)phenylacetic acid

생성물 1

HCID 27600862-(4-Methylsulfanylphenyl)ethanol수율 86.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5.5 ml 1 M borane-tetrahydrofuiran complex was slowly added to a solution of 1 g (5.5 mmole) 4-(methylmercapto)phenyl acetic acid in 5 ml tetrahydrofuran at −10° C. The reaction mixture was allowed to reach room temperature and the reaction was followed by TLC. After completion 10 ml methanol was added and the solvents were evaporated. Diethyl ether and 2 M sodium hydroxide was added, the phases were separated, the organic phase was dried, filtered and evaporated in vacuo to give 0.8 g (yield 84.4%) of 2-[4-(methylmercapto)phenyl]-1-ethanol.

후처리

  1. customto reach room temperature
  2. customthe solvents were evaporated
  3. additionDiethyl ether and 2 M sodium hydroxide was added
  4. customthe phases were separated
  5. customthe organic phase was dried
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-353e9ef6816b4c148bc6c84bd2d7614d
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288096B1

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