참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 5-[(Tert-butyldimethylsilyl)oxy]pentan-2-one | HCID 10680263 | — |
| 생성물 | Ethyl 7-[(tert-butyldimethylsilyl)oxy]-2,4-dioxoheptanoate | HCID 54073086 | 16.6% |
반응 단계
Diethyl oxalate (4.048 g, 37.7 mmol) was added to solid sodium ethoxide (0.472 g, 69.3 mmol) at 0° C. followed by slow addition of 5-(tert-butyl-dimethyl-silanyloxy)-pentan-2-one (1.500 g, 69.3 mmol). The resulting orange solution was stirred at 0° C. for 10 minutes and at room temperature for 3 h. Purification by flash chromatography (19:1 hexanes:EtOAc to 9:1 EtOAc:MeOH) provided the title compound (1.982 g); MS 317 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06288120B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_09 |
|---|
| ORD ID | ord-27e5f57cbf0242b7b46f3a85fed10a0b |
|---|
| 출처 메모 | uspto-grants-2001_09 |
|---|
