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Ammonium Hydroxide → 4-[1,1'-Biphenyl]-4-yl-6-chloro-1,3,5-triazin-2-amine

HRID 1595941
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HRID 1595941 반응식
[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11](Cl)[N:10]=[C:9]([Cl:14])[N:8]=2)=[CH:3][CH:2]=1.[OH-].[NH4+:22]>CCOCC.O1CCCC1.O>[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:2]=[CH:3][C:4]([C:7]2[N:8]=[C:9]([Cl:14])[N:10]=[C:11]([NH2:22])[N:12]=2)=[CH:5][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 14923Ammonium HydroxideHCID 223522432-(4-Biphenylyl)-4,6-dichloro-1,3,5-triazine

생성물 1

HCID 217054854-[1,1'-Biphenyl]-4-yl-6-chloro-1,3,5-triazin-2-amine수율 12%

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 8028
Tetrahydrofuran
용매

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온도
0 °C

실험 절차

A mixture of 2-[1,1′-biphenyl]-4-yl-4,6-dichloro-1,3,5-triazine (Example 63A) (0.804 g, 2.67 mmol) in 40 mL ether and concentrated ammonium hydroxide (2 mL, 30 mmol) in tetrahydrofuran (30 mL) was stirred at 0° C. for 60 minutes and at ambient temperature for 20 minutes. The reaction was reduced in volume, diluted with water, and the precipitate was collected, rinsed with water and ether, and dried to provide the desired compound (0.090 g, 12%).

후처리

  1. customthe precipitate was collected
  2. washrinsed with water and ether
  3. customdried

출처 및 근거

ORD 기록
ord-3b5633d02a60418e897ed67d656c6b0b
출처 데이터셋
uspto-grants-2001_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06288228B1

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