Ammonium nitrate → 4,4'-Dibromobenzil

HRID 1595953노트

반응식

HRID 1595953 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[OH:11])=[O:9])=[CH:4][CH:3]=1.[N+]([O-])([O-])=O.[NH4+]>C(O)(=O)C.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([Br:18])=[CH:16][CH:17]=2)=[O:11])=[O:9])=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 22985Ammonium nitrateHCID 39382431,2-Bis(4-bromophenyl)-2-hydroxyethanone

생성물 1

HCID 964304,4'-Dibromobenzil수율 64.2%

시약·촉매·용매 2

HCID 8895Cupric acetate촉매HCID 176Acetic Acid용매

실험 절차

A solution of 4,4′-dibromobenzoin (20.2 g, 0.055 mol), ammonium nitrate (4.6 g, 0.0575 mol) and copper(II) acetate (0.100 g, 0.0005 mol) in 80 percent aqueous acetic acid (200 mL) is heated at reflux for three hours. The reaction mixture is cooled to room temperature and the product which crystallizes out is filtered off, washed with ethanol and dried, giving 13.0 g (64 percent) of product as a light yellow solid, mp 226° C. to 228° C. 1H NMR (CDCl3) δ 7.83 (d, J=8.5 Hz, 4H), 7.66 (d, J=8.5 Hz, 4H); 13C NMR (CDCl3) δ 192.25, 132.44, 131.45, 131.22, 130.7.

후처리

  1. temperatureat reflux for three hours
  2. customthe product which crystallizes out
  3. filtrationis filtered off
  4. washwashed with ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-3be651f63c564bb6a69fac902a16e708
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288188B1

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