Methyl Bromide → 2-Bromo-6-ethoxynaphthalene

HRID 1596119노트

반응식

HRID 1596119 반응식
Br[CH3:2].[Br:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9](O)[CH:8]=[CH:7]2.[C:15](=[O:18])([O-])[O-].[K+].[K+]>CC(C)=O>[Br:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:18][CH2:15][CH3:2])[CH:10]=2)[CH:5]=1

참가 물질

5

반응물 3

HCID 6323Methyl BromideHCID 11430Potassium CarbonateHCID 271446-Bromo-2-naphthalenol

생성물 1

HCID 2368582-Bromo-6-ethoxynaphthalene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

This experimental procedure is an O-alkylation. A solution of bromomethane (48.90 g, 0.45 mol) is added dropwise to a stirred refluxing mixture of 6-Bromo-2-naphthol (40.00 g, 0.18 mol) and potassium carbonate (63.00 g, 0.46 mol) in acetone. The stirred mixture is heated under reflux for 24 hours (ie until glc analysis reveals a complete reaction). The potassium carbonate is filtered off, water is added to filtrate and the product is recrystallised from ethanol to give a yield of 43.92 g (97%).

후처리

  1. temperaturerefluxing
  2. temperatureThe stirred mixture is heated
  3. temperatureunder reflux for 24 hours (ie until glc analysis
  4. customa complete reaction)
  5. filtrationThe potassium carbonate is filtered off
  6. additionwater is added to filtrate
  7. customthe product is recrystallised from ethanol
  8. customto give a yield of 43.92 g (97%)

출처 및 근거

ORD 기록
ord-add5e0c5cb664018a2112c8f826da0b9
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291034B1

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