Ammonia → 3-Amino-4-fluorophenol

HRID 1596243노트

반응식

HRID 1596243 반응식
N.[F:2][C:3]1[CH:9]=[CH:8][C:7]([O:10]C(OC)=O)=[CH:6][C:4]=1[NH2:5]>CO>[F:2][C:3]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:4]=1[NH2:5]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 217015692-Fluoro-5-methoxycarbonyloxyaniline

생성물 1

HCID 135191803-Amino-4-fluorophenol수율 73%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Concentrated aqueous ammonia (15 ml) was added to a solution of 2-fluoro-5-methoxycarbonyloxyaniline (400 mg, 2.16 mmol) in methanol (10 ml). The mixture was stirred for 2 hours and most of the solvent was removed by evaporation. The resulting suspension was diluted with water, acidified to pH7 and extracted with ethyl acetate. The organic extracts were washed with water, dried (MgSO4) and solvent removed by evaporation to give 2-fluoro-5-hydroxyaniline (200 mg, 73%).

후처리

  1. customwas removed by evaporation
  2. additionThe resulting suspension was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with water
  5. dry with materialdried (MgSO4) and solvent
  6. customremoved by evaporation

출처 및 근거

ORD 기록
ord-ca1253032bf3453b8fcabf92739bff90
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291455B1

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