Trifluoroacetic acid → HCID 21702192, 화합물

HRID 1596539

반응식

HRID 1596539 반응식
C([O:5][C:6]([C:8]1[C:15]2[C:11]([N:12]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([Cl:34])[CH:28]=3)[CH:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH:14]=2)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:6]([C:8]1[C:15]2[C:11]([N:12]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([Cl:34])[CH:28]=3)[CH:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH:14]=2)=[CH:10][CH:9]=1)([OH:7])=[O:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 21702180Benzyl 4-tert-butoxycarbonyl-1-(3,4-dichlorobenzyl)cyclopenta[b]pyrrole-2-carboxylate

생성물 1

HCID 21702192HCID 21702192, 화합물수율 98.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Benzyl 4-tert-butoxycarbonyl-1-(3,4dichlorobenzyl)cyclopenta[b]pyrrole-2-carboxylate (0.7 g) was dissolved in methylene chloride (10 mL) and TFA (3 mL) was added. Stirring was continued for 24 hours and the solvents were removed in vacuo to afford a pale oil. The oil slowly solidified on standing to afford the title product (0.61 g, 98%), NMR d(DMSO) 2.40 (4H, m), 3.70 (1H, t), 5.10 (2H, s), 5.40 (2H, AB d), 6.70 (1H, s), 6.90 (1H, d), 7.30 (6H, m), 7.50 (1H, d); M/z (−) 444, 442 (M-H+).

후처리

  1. customthe solvents were removed in vacuo
  2. customto afford a pale oil

출처 및 근거

ORD 기록
ord-eddf44201f204b919c44a3656eca1bf0
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291507B1

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