Chloroacetyl chloride → HCID 21938676, 화합물

HRID 1596656노트

반응식

HRID 1596656 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1.[Cl:18][CH2:19][C:20](Cl)=[O:21]>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[N:10]([C:20](=[O:21])[CH2:19][Cl:18])[C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 21938673HCID 21938673, 화합물

생성물 1

HCID 21938676HCID 21938676, 화합물

실험 절차

A mixture of 230 g (0.9 mol) N-(2′-chloro-4′,6′-difluorophenyl)-4-methylaniline and 325 ml (4.06 mol) of chloroacetyl chloride is heated under a nitrogen atmosphere for one hour at 50°. The solvent is evaporated under reduced pressure to give an oil to which 200 ml of chlorobenzene is added. The solvent is evaporated under reduced pressure to completely remove the chloroacetyl chloride, giving N-(2′-chloro4′,6′-difluorophenyl)-N-chloroacetyl-4-methylaniline as an oil.

후처리

  1. temperatureis heated under a nitrogen atmosphere for one hour at 50°
  2. customThe solvent is evaporated under reduced pressure
  3. customto give an oil to which 200 ml of chlorobenzene
  4. additionis added
  5. customThe solvent is evaporated under reduced pressure
  6. customto completely remove the chloroacetyl chloride

출처 및 근거

ORD 기록
ord-49b8733102eb4dc2aec0d3afd2874b44
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291523B1

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