Aluminium lithium hydride → 1-[(1-Aminopropan-2-YL)oxy]-2-methoxybenzene

HRID 1596782노트

반응식

HRID 1596782 반응식
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH:6]([CH3:9])[C:7]#[N:8].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH:6]([CH3:9])[CH2:7][NH2:8]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 217030942-(2-Methoxy-phenoxy)-propionitrile

생성물 1

HCID 217030831-[(1-Aminopropan-2-YL)oxy]-2-methoxybenzene수율 7%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
65 °C

실험 절차

To a solution of 2-(2-methoxy-phenoxy)-propionitrile (3.91 g, 0.022 mol) in anhydrous ethyl ether (30 ml) was added lithium aluminum hydride (1.0 M, 44 ml, 0.044 mol). The mixture was heated at 65° C. for 18 hours and the reaction was quenched with water (3 ml), 15% NaOH (3 ml) and water (9 ml). The resulting material was filtered through celite. The celite was washed with methanol (200 ml), and the solvent was removed under vacuum. Chromatography (10% methanol-methylene chloride) afforded 0.26 g (7%) of product as yellow oil. MS EI m/e 181

후처리

  1. customthe reaction was quenched with water (3 ml), 15% NaOH (3 ml) and water (9 ml)
  2. filtrationThe resulting material was filtered through celite
  3. washThe celite was washed with methanol (200 ml)
  4. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-3a7a633b456e41249f80d843e25042fe
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291683B1

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