2-Naphthol → 1-(4-Morpholinophenyl)-1-phenylprop-2-yn-1-ol

반응식

[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[O:18]C4C=CC5C(C=4[CH:15]=[CH:14]3)=CC=CC=5)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C1C2C(=CC=CC=2)C=CC=1O>>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:8]=[CH:9][C:10]([C:13]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)([OH:18])[C:14]#[CH:15])=[CH:11][CH:12]=2)[CH2:5][CH2:6]1

참가 물질

반응물 2

HCID 86632-Naphthol

HCID 216988013(4-Morpholinophenyl)-3-phenyl-3h-naphtho[2,1-b]pyran

생성물 1

HCID 2867411-(4-Morpholinophenyl)-1-phenylprop-2-yn-1-ol수율 71%

실험 절차

3(4-Morpholinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran from 2-naphthol and 1(4-morpholinophenyl)-1-phenylprop-2-yn-1-ol (yield=71% after recrystallisation from EtOAc and hexane, m.p.=186-187° C. (uncorrected), λmax in toluene=500 nm, i.e. red).

출처 및 근거

ORD 기록: ord-671b825a9d164ec0802a317c8acee2a8
출처 데이터셋: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06294112B1

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